Pantoprazole Uses, Dosage & Side Effects

The FDA approves these medications for treating GERD as a short-term eight-week treatment. Omeprazole reduces normal and excessive stomach acid levels, regardless of the cause. Omeprazole begins working about an hour after taking a dose; however, it takes one to four days of treatment to reach its full benefit.

  1. Pantoprazole undergoes little first-pass metabolism, resulting in an absolute bioavailability of approximately 77%.
  2. While the drug is effective for peptic ulcer disease, there have been many reports regarding overdose.
  3. This medicine is a yellow, oval, enteric-coated, tablet imprinted with “H125”.
  4. Pantoprazole oral tablet can interact with other medications, herbs, or vitamins you might be taking.

In fact, this was the most common side effect reported by people in studies. In addition, headaches can be a symptom of various conditions. But it is unknown whether the drug may affect a breastfed child. If you’re breastfeeding or planning to breastfeed, talk with your doctor before taking pantoprazole. It is unknown if pantoprazole is safe to take during pregnancy.

More common side effects

Keep PROTONIX and all medicines out of the reach of children. In a population PK analysis, total clearance increased with increasing bodyweight in a non-linear fashion. The total clearance also increased with increasing age only in children under 3 years of age.

Administration Instructions

After administration of a single or multiple oral 40 mg doses of PROTONIX Delayed-Release Tablets, the peak plasma concentration of pantoprazole was achieved in approximately 2.5 hours, and Cmax was 2.5 μg/mL. Pantoprazole undergoes little drug-induced tremor first-pass metabolism, resulting in an absolute bioavailability of approximately 77%. Pantoprazole absorption is not affected by concomitant administration of antacids. Advise a pregnant woman of the potential risk to a fetus.

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use PROTONIX for a condition for which it was not prescribed. Do not give PROTONIX to other people, even if they have the same symptoms that you have.

Side effects

Talk with your doctor or pharmacist to see which treatment option might be right for you. Some OTC treatments may be taken together with pantoprazole, if pantoprazole doesn’t relieve your symptoms quickly enough. For example, OTC antacids may be used with pantoprazole.

Precautions for Protonix

But throat pain and other throat issues can be symptoms of the conditions pantoprazole treats. Some factors that may affect your risk of side effects with pantoprazole include other health conditions you have or other medications you take. Proton pump inhibitors (such as pantoprazole) may increase your risk for bone fractures, especially with longer use, higher doses, and in older adults. Talk with your doctor or pharmacist about ways to prevent bone loss/fracture, such as by taking calcium (such as calcium citrate) and vitamin D supplements.

For the treatment of conditions where the stomach produces too much acid, pantoprazole is usually taken twice a day. The delayed-release tablets are usually taken with or without food, and the granules are usually taken 30 minutes before a meal. Follow the directions on your prescription label carefully, and ask your doctor or partial hospitalization and intensive outpatient programs resnick neuropsychiatric hospital pharmacist to explain any part you do not understand. Do not take more or less of it or take it more often or for a longer period of time than prescribed by your doctor. It can also be found in quadruple regimens for the treatment of H. Pantoprazole given once daily results in increasing inhibition of gastric acid secretion.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns, or for more information about this medicine. Pantoprazole is a proton pump inhibitor that decreases acid secretion in the stomach and may be given to relieve the symptoms of heartburn or to allow inflamed tissue in the gastrointestinal tract to heal. Pantoprazole tablets are delayed-release and should not be split, crushed, or chewed; pantoprazole oral granules are available. This list does not contain all types of drugs that may interact with pantoprazole oral tablets. Your doctor or pharmacist can tell you more about these interactions and any others that may occur with the use of pantoprazole oral tablets. Call your doctor right away if you have an allergic reaction to pantoprazole oral tablets.

You can ask your doctor or pharmacist for information about PROTONIX that is written for health professionals. Patients taking PROTONIX consumed significantly fewer antacid tablets per day than those taking placebo. CYP2C19 displays a known genetic polymorphism due to its deficiency in some subpopulations (e.g., approximately 3% of Caucasians and African-Americans and 17% to 23% of Asians are poor metabolizers). Although these subpopulations of pantoprazole poor metabolizers have elimination half-life values of 3.5 to 10 hours in adults, they still have minimal accumulation (23% or less) with once-daily dosing. For adult patients who are CYP2C19 poor metabolizers, no dosage adjustment is needed.

There were no drug-related findings in maternal animals. The femur findings included lower total area, bone mineral content and density, periosteal and endosteal circumference, and cross-sectional moment of inertia. There were no microscopic changes in the distal femur, proximal tibia, or stifle joints. In a 24-month carcinogenicity study, B6C3F1 mice were treated orally with doses of 5 to 150 mg/kg/day of pantoprazole, 0.5 to 15 times the recommended human dose based on body surface area. In the liver, treatment with 150 mg/kg/day produced increased incidences of hepatocellular adenomas and carcinomas in female mice.


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